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Updated: Jul 8, 2025
00:06
Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
Published on: August 23, 2019
7.1K
An evolution-based framework for describing human gut bacteria
Benjamin A Doran1,2, Robert Y Chen3, Hannah Giba1,4
1Duchossois Family Institute, University of Chicago, Chicago, IL, 60637.
Biorxiv : the Preprint Server for Biology
|December 18, 2023
Summary
Understanding bacterial strains in the human gut microbiome is key. Co-evolutionary patterns reveal hidden structures within species, enabling prediction of metabolic functions and consortium engineering.
Area of Science:
- Microbiology
- Genomics
- Systems Biology
Background:
- The human gut microbiome harbors diverse bacterial strains within species, presenting challenges for biological description beyond taxonomy.
- Strain-level variation is genetically complex, hindering meaningful classification and functional prediction.
Conclusions:
- Bacterial strain-level variation exhibits a meaningful organization based on evolutionary history.
- A novel schema for describing bacterial strains using co-evolutionary signatures is proposed.
- This approach enhances understanding of gut microbiome composition and function.
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