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Bearded capuchin monkey as a model for Alzheimer's disease research
Roberta Diehl Rodriguez1, Maria Clotilde Tavares2, Sonia Maria Brucki3
1Faculdade de Medicina da Universidade de São Paulo.
Research Square
|December 18, 2023
Summary
Aged capuchin monkeys spontaneously develop Alzheimer-type pathology, including beta-amyloid plaques and tau tangles. This finding suggests capuchins may serve as a valuable natural animal model for Alzheimer
Area of Science:
- Neuroscience
- Primatology
- Pathology
Background:
- Alzheimer's disease research lacks natural animal models, hindering progress.
- Non-human primates offer a closer phylogenetic link to humans than rodent models.
- Capuchin monkeys are noted for their cognitive abilities and tool use.
Conclusions:
- Aged capuchin monkeys can spontaneously develop Alzheimer's disease pathology.
- These findings support the use of capuchin monkeys as a suitable animal model for Alzheimer's research.
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