BDNF signaling requires Matrix Metalloproteinase-9 during structural synaptic plasticity
Diana Legutko1,2, Bożena Kuźniewska1,3, Katarzyna Kalita1
1BRAINCITY, Laboratory of Neurobiology, The Nencki Institute, 02-093 Warsaw, Pasteura 3, Poland.
Biorxiv : the Preprint Server for Biology
|December 18, 2023
Summary
Matrix metalloproteinase-9 (MMP-9) is crucial for structural long-term potentiation (sLTP), a key process in learning and memory. MMP-9 enables brain-derived neurotrophic factor (BDNF) maturation and TrkB receptor activation, essential for synaptic plasticity.
Area of Science:
- Neuroscience
- Molecular Biology
- Cell Biology
Background:
- Synaptic plasticity, vital for learning and memory, involves structural long-term potentiation (sLTP) of dendritic spines.
- sLTP relies on brain-derived neurotrophic factor (BDNF) signaling through its receptor, TrkB.
- Aberrant synaptic plasticity is implicated in neuropsychiatric disorders.
Conclusions:
- MMP-9 plays a critical role in mediating sLTP.
- MMP-9 acts via an autocrine mechanism, maturing BDNF to activate TrkB.
- These findings elucidate a novel pathway regulating synaptic plasticity.
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