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Colchicine Poisoning: A Rare Case.

Andreia Amaral¹, Diogo Ferreira da Silva¹, Maria Beatriz Sampaio¹

¹Internal Medicine, Centro Hospitalar Universitário de Lisboa Central, Lisbon, PRT.

|December 18, 2023

Summary

This summary is machine-generated.

Colchicine overdose is rare but dangerous, potentially causing severe toxicity or death. This case highlights colchicine

Keywords:

case reports colchicine poisoning rare cause of pleural effusion substance-related disorders treatment-related toxicity

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Area of Science:

Toxicology
Internal Medicine
Cardiology

Background:

Colchicine, a medication used for gout and familial Mediterranean fever, has a narrow therapeutic index.
Colchicine intoxication is uncommon but associated with significant morbidity and mortality (10% fatality rate).
Rapid recognition and management are critical for improving outcomes in colchicine overdose cases.

Observation:

A 50-year-old female presented 24 hours after ingesting 10 mg of colchicine.
Initial presentation included leukocytosis, neutrophilia, and elevated lactate dehydrogenase (LDH).
The patient later developed chest pain, respiratory distress, and a right-sided pleural effusion.

Findings:

Diagnostic workup revealed partial respiratory failure and a right-sided pleural effusion.
Imaging studies, including chest X-ray and CT scan, confirmed the pleural effusion.
The pleural effusion was attributed to cardiac dysfunction secondary to colchicine intoxication.

Implications:

This case underscores the potential for colchicine overdose to induce cardiac complications, including pleural effusion.
Early identification of colchicine toxicity symptoms is vital for timely intervention.
Understanding these toxic effects can guide treatment strategies to reduce colchicine-induced morbidity and mortality.