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RNA-binding proteins regulating the CD44 alternative splicing

Diana Maltseva1, Alexander Tonevitsky1,2

  • 1Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.

Frontiers in Molecular Biosciences
|December 18, 2023
PubMed

Insights

Alternative splicing of CD44 (a cell surface glycoprotein) is altered in cancer, impacting cell functions. RNA-binding proteins regulate these CD44 splicing changes, offering potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cell Biology

Background:

  • Alternative splicing dysregulation is a hallmark of cancer.
  • CD44 isoforms play critical roles in normal and malignant cells, influencing epithelial to mesenchymal transition (EMT) and cancer stem cell phenotypes.
  • CD44 isoform switching is vital for pluripotency in normal cells and malignant transformation.

Purpose of the Study:

  • To review the regulation of CD44 alternative splicing by RNA-binding proteins.
  • To highlight the significance of CD44 isoforms in cancer progression.
  • To explore the therapeutic potential of targeting CD44 splicing.

Main Methods:

  • Literature review of studies on CD44 alternative splicing.
  • Analysis of RNA-binding protein interactions with CD44 pre-mRNA.
  • Integration of data on CD44 function in cancer and normal cells.

Main Results:

  • Specific RNA-binding proteins modulate CD44 alternative splicing.
  • CD44 isoform expression is altered during EMT and in cancer stem cells.
  • Dysregulated CD44 splicing contributes to oncogenesis.

Conclusions:

  • RNA-binding proteins are key regulators of CD44 alternative splicing.
  • Targeting CD44 splicing represents a promising therapeutic strategy for cancer.
  • Understanding CD44 splicing regulation is crucial for developing novel cancer treatments.
Keywords:
CD44 alternative splicing regulationCD44 isoformESRP1RNA-binding proteincancer

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