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Updated: Jul 8, 2025

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Facilitating Ir-Catalyzed C-H Alkynylation with Electrochemistry: Anodic Oxidation-Induced Reductive Elimination
Xiaohan Ye1, Chenhuan Wang1, Shuyao Zhang1
1Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Abstract:
An electrochemical approach in promoting directed C-H alkynylation with terminal alkyne via iridium catalysis is reported. This work employed anodic oxidation of Ir(III) intermediate (characterized by X-ray crystallography) to promote reductive elimination, giving the desired coupling products in good yields (up to 95%) without the addition of any other external oxidants. This transformation is suitable for various directing groups with H2 as the only by-product, which warrants a high atom economy and practical oxidative C-C bond formation under mild conditions.
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