Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental acute thrombotic stroke in baboons.

G J Del Zoppo, B R Copeland, L A Harker

    Stroke
    |November 1, 1986
    PubMed
    Summary

    This study developed a baboon model for experimental stroke, demonstrating that antithrombotic therapy significantly reduces platelet aggregation and microvascular occlusion in the affected brain region.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Thrombolytic therapy in acute ischemic stroke.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
    Same author

    Approach to the treatment, characterization and diagnosis of an acquired auto-antibody directed against factors prothrombin, factor X and factor IX: a case report and review of the literature.

    Haemophilia : the official journal of the World Federation of Hemophilia·2011
    Same author

    The neurovascular unit in the setting of stroke.

    Journal of internal medicine·2010
    Same author

    Inflammation and the neurovascular unit in the setting of focal cerebral ischemia.

    Neuroscience·2008
    Same author

    Vascular matrix adhesion and the blood-brain barrier.

    Biochemical Society transactions·2006
    Same author

    Focal cerebral ischemia and hemostasis: a PAI-1 conundrum.

    Journal of thrombosis and haemostasis : JTH·2005

    Area of Science:

    • Neurology
    • Cardiovascular Research
    • Experimental Medicine

    Background:

    • Cerebrovascular thrombosis is a leading cause of stroke.
    • Developing reliable animal models is crucial for studying stroke pathophysiology and testing therapies.
    • Antithrombotic agents are vital in managing thrombotic events.

    Purpose of the Study:

    • To characterize a baboon model of acute cerebrovascular thrombosis.
    • To evaluate the efficacy of antithrombotic therapy in this model.

    Main Methods:

    • A balloon cuff was used to occlude the middle cerebral artery (MCA) in baboons.
    • Computerized tomography (CT) and neuropathology assessed infarction volume.
    • 111In-platelet imaging and histology quantified thrombotic burden.

    Related Experiment Videos

  • Animals were pretreated with heparin and ticlopidine to assess antithrombotic effects.

    • Main Results:

    • The model reliably induced stroke with contralateral hemiparesis and striatal infarction.
    • 111In-platelet imaging confirmed platelet aggregation in the occluded MCA territory.
    • Heparin and ticlopidine significantly reduced platelet activity and microvascular occlusion (p < 0.01).

    Conclusions:

    • The baboon MCA occlusion model is suitable for studying antithrombotic therapies.
    • Antithrombotic therapy effectively mitigates thrombosis in this experimental stroke model.
    • This model provides a platform for further research into stroke treatment strategies.