Related Experiment Video
Updated: Jul 8, 2025
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
14.9K
High blood viscosity in acute ischemic stroke.
Jihoon Kang1, Ju Seok Oh2, Beom Joon Kim1
1Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Frontiers in Neurology
|December 18, 2023
Summary
Elevated blood viscosity is linked to ischemic stroke. Measuring blood viscosity upon hospital arrival may help distinguish ischemic stroke from stroke mimics.
Area of Science:
- Biomedical Engineering
- Neurology
- Hematology
Background:
- Blood viscosity influences shear stress at vessel walls.
- Limited evidence exists on blood viscosity's impact on thrombogenesis and acute stroke.
- Investigating blood viscosity's role in stroke is crucial.
Purpose of the Study:
- To investigate the effect of blood viscosity on stroke.
- To assess the clinical utility of immediate blood viscosity measurements in suspected stroke patients.
Main Methods:
- Enrolled patients with suspected stroke within 24 hours of symptom onset.
- Used point-of-care testing for blood viscosity measurements before fluid infusion.
- Compared blood viscosity in ischemic stroke, hemorrhagic stroke, and stroke mimic groups.
Main Results:
- Blood viscosity was significantly higher in ischemic stroke patients (24.2 cP) compared to stroke mimics (17.8 cP) at 10 rad/sec (p < 0.001).
- This difference was consistent across multiple oscillatory frequencies.
- The area under the receiver operating curve for differentiating stroke from mimics was 0.79.
Conclusions:
- Ischemic stroke is associated with increased whole blood viscosity.
- Blood viscosity measurements show potential clinical utility in differentiating ischemic stroke from other conditions.
More Related Videos
Related Concept Videos
01:16Vascular Spasm
1.4K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
1.4K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
708
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
708
01:27Regulation of Stroke Volume
3.3K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
3.3K