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Does cerebral vasospasm result from denervation supersensitivity?

T A Duff, J A Feilbach, G Scott

    Stroke
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Adrenergic denervation does not cause cerebral vasospasm. Hemoglobin in blood is a more likely cause of cerebral vasospasm than other agents, according to this study on cat arteries.

    Area of Science:

    • Neuroscience
    • Vascular Biology
    • Pharmacology

    Background:

    • Cerebral vasospasm is a serious complication following subarachnoid hemorrhage.
    • Denervation supersensitivity has been proposed as a potential mechanism contributing to cerebral vasospasm.
    • The role of adrenergic denervation in cerebral vasospasm requires further investigation.

    Purpose of the Study:

    • To investigate the role of adrenergic denervation supersensitivity in the development of cerebral vasospasm.
    • To compare the effects of various agents, including blood products, on normal and denervated feline cerebral arteries.
    • To identify potential causative agents of cerebral vasospasm.

    Main Methods:

    • Adrenergic denervation of the cat basilar artery was induced via superior cervical ganglion resection or 6-hydroxydopamine injection.

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  • In vivo dose-response studies were conducted using topical applications of serotonin, norepinephrine, epinephrine, fresh blood, and incubated blood.
  • In vitro analysis of incubated cat blood was performed to determine changes in agent concentrations over time.

    • Main Results:

    • No significant differences in vasospasm response were observed between normal and denervated arteries when exposed to serotonin, norepinephrine, epinephrine, or blood.
    • In vitro incubation of cat blood showed decreased levels of serotonin, norepinephrine, and epinephrine over 14 days.
    • Hemoglobin and methemoglobin levels increased in incubated blood up to Day 14.

    Conclusions:

    • Adrenergic denervation is not the primary cause of cerebral vasospasm.
    • Hemoglobin, rather than adrenergic agents or other tested substances, is a more probable causative agent in cerebral vasospasm.
    • These findings suggest a significant role for hemoglobin in the pathophysiology of cerebral vasospasm.