Bioengineering and the cervix: The past, current, and future for addressing preterm birth

Area of Science:

• Biomedical Engineering
• Obstetrics
• Reproductive Science

Background:

• The uterine cervix is crucial during pregnancy, acting as a barrier to maintain the fetus and a dilating structure for birth.
• Premature cervical softening and dilation lead to preterm birth, a significant complication in pregnancy.
• Current preterm birth rates remain a challenge, necessitating innovative solutions.

Purpose of the Study:

• To highlight existing and emerging bioengineering technologies for diagnosing, preventing, and understanding premature cervical remodeling.
• To identify open research areas where bioengineers can address preterm birth.

Main Methods:

• Review of current and novel bioengineering technologies.
• Analysis of research gaps in cervical remodeling and preterm birth.

Main Results:

• A range of technologies are being developed to diagnose and manage premature cervical changes.
• Emerging innovations offer potential for improved prevention and understanding of preterm birth.

Conclusions:

• Bioengineering plays a vital role in addressing the persistent challenge of preterm birth.
• Significant opportunities exist for bioengineers to advance research in cervical remodeling and preterm birth prevention.