Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Loading layered double hydroxide nanoarray catalysts on a micro-curved substrate for kinetics-favorable water electrolysis reaction.

Chemical communications (Cambridge, England)·2026

Same author

Beyond the vacuum: modeling the solid-liquid interface for gas-involving electrocatalysis.

Chemical communications (Cambridge, England)·2026

Same author

Gestational lipid profile partially mediates adverse obstetric outcomes associated with polycystic ovary syndrome: a multicentre cohort study in China.

Lipids in health and disease·2026

Same author

Inhibitory effect and mechanism of Nb<sub>2</sub>C nanochaperone on bovine serum albumin unfolding.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026

Same author

Transcranial direct current stimulation for perioperative depression in breast cancer surgery: a randomized controlled trial.

Translational psychiatry·2026

Same author

Manipulating ligand effects over Pt-Ni solid-solution alloys for highly efficient ammonia electrooxidation.

Chemical communications (Cambridge, England)·2026

Search research articles

Related Experiment Video

Updated: Jul 8, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

Monkeypox Virus Crosstalk with HIV: An Integrated Skin Transcriptome and Machine Learning Study.

Xueyao Cai¹, Tianyi Zhou^2,3, Wenjun Shi⁴

¹Department of Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha 410013, China.

|December 18, 2023

Summary

This study reveals shared molecular pathways between monkeypox virus (MPXV) and human immunodeficiency virus (HIV). Identifying common genes and pathways offers new strategies for managing MPXV in HIV patients.

More Related Videos

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Published on: September 25, 2018

An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells

An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells

Published on: August 15, 2012

Related Experiment Videos

Last Updated: Jul 8, 2025

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

Published on: March 5, 2022

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Published on: September 25, 2018

An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells

An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells

Published on: August 15, 2012

Area of Science:

Virology
Immunology
Genomics

Background:

The monkeypox virus (MPXV) outbreak poses a significant public health threat.
Individuals with human immunodeficiency virus (HIV) experience disproportionately severe MPXV outcomes and higher mortality.
Shared molecular mechanisms between MPXV and HIV are not well understood.

Purpose of the Study:

To identify common differentially expressed genes (DEGs) between MPXV and HIV infections.
To elucidate shared molecular pathways and potential therapeutic targets.
To validate key biomarkers using machine learning approaches.

Main Methods:

Analysis of two public gene expression datasets (GSE219036, GSE184320) to find common DEGs.
Functional enrichment analyses including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG).
Construction of protein-protein interaction (PPI) networks and machine learning (ML) validation of hub genes.

Main Results:

Identified 59 common DEGs between MPXV and HIV.
Highlighted shared pathways such as ERK cascade, NF-κB signaling, and immune responses.
Identified and validated five key genes (SPRED1, SPHK1, ATF3, AKT3, AKT1S1) with significant immune correlations.

Conclusions:

MPXV and HIV share common pathogenic mechanisms.
Key genes and pathways identified provide novel insights into co-infection pathogenesis.
Findings offer opportunities for developing targeted management strategies for HIV patients co-infected with MPXV.