Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central nervous system defects in early human abortuses.

J E Bell

    Developmental Medicine and Child Neurology
    |June 1, 1979
    PubMed
    Summary

    This study examined thirteen spontaneously aborted embryos with central nervous system (CNS) defects, finding widespread abnormalities in brain and spinal cord development. Findings were compared to childhood CNS defects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    West Nile Virus Transmission Suitability Modeling for <i>Culex pipiens</i> via Temperature and Humidity.

    GeoHealth·2026
    Same author

    A systematic review of the effects of temperature and precipitation on pollen concentrations and season timing, and implications for human health.

    International journal of biometeorology·2021
    Same author

    Relating coccidioidomycosis (valley fever) incidence to soil moisture conditions.

    GeoHealth·2017
    Same author

    Application of a Novel Brain Arteriovenous Malformation Endovascular Grading Scale for Transarterial Embolization.

    AJNR. American journal of neuroradiology·2015
    Same author

    N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning.

    The European journal of neuroscience·2013
    Same author

    Characterization of a novel bidirectional distraction spinal cord injury animal model.

    Journal of neuroscience methods·2011

    Area of Science:

    • Developmental Biology
    • Teratology
    • Neuroscience

    Background:

    • Congenital central nervous system (CNS) defects are a significant cause of spontaneous abortion.
    • Understanding the pathology of these defects is crucial for prenatal diagnosis and management.

    Purpose of the Study:

    • To investigate the macroscopic and histological features of CNS defects in spontaneously aborted human embryos.
    • To compare the observed defects with known pathologies of CNS malformations in childhood.

    Main Methods:

    • Macroscopic examination and serial sectioning of thirteen spontaneously aborted embryos with CNS defects.
    • Histological assessment of the CNS, skeletal axis, neural crest derivatives, and viscera.
    • Comparison with seven control embryos.

    Main Results:

    • Observed defects included anencephaly, spina bifida, encephalocele, iniencephaly, and cyclops.
    • Absence of brain tissue was noted in most anencephalic embryos.
    • Spinal cord tissue was absent at the lesion site in most spina bifida cases, with associated vertebral column abnormalities.

    Conclusions:

    • The study highlights the spectrum of CNS malformations in early development.
    • Findings suggest potential insights into the pathogenesis of congenital CNS defects and their relation to childhood conditions.

    Related Experiment Videos