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Recent advances in Pd-catalyzed asymmetric cyclization reactions

Bing Xu^1,2, Quanpu Wang¹, Chao Fang¹

¹Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, P. R. China. zhanmingzhang@fudan.edu.cn.

Chemical Society Reviews

|December 18, 2023

Summary

Recent progress in transition metal-catalyzed asymmetric cyclization reactions provides access to chiral molecules. Chiral palladium catalysts are key to these enantioselective transformations, driving innovation in synthesis.

Area of Science:

Organic Chemistry
Catalysis
Asymmetric Synthesis

Background:

Chiral carbo- and hetero-cycles are crucial building blocks in pharmaceuticals, agrochemicals, and materials.
Transition metal-catalyzed asymmetric cyclization reactions offer efficient routes to these valuable structures.
Chiral palladium catalysts exhibit remarkable efficacy in promoting enantioselective cyclization.

Purpose of the Study:

To review the latest advancements in enantioselective palladium-catalyzed cyclization reactions.
To cover developments over the past eleven years.
To organize findings based on distinct transformation types.

Main Methods:

Comprehensive literature survey of enantioselective palladium-catalyzed cyclization reactions.
Categorization of reactions based on the specific transformations involved.
Analysis of recent developments and key catalytic systems.

Main Results:

Significant progress has been made in developing diverse chiral carbo- and hetero-cycles.
Chiral palladium catalysis has proven highly effective for numerous enantioselective cyclizations.
A wide array of transformations has been achieved with high enantioselectivity.

Conclusions:

Enantioselective palladium-catalyzed cyclization reactions are powerful tools for synthesizing complex chiral molecules.
The field has seen substantial innovation in the last eleven years.
This review consolidates recent progress, highlighting the versatility and impact of palladium catalysis in asymmetric synthesis.

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