Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease
Svetlana Ukraintseva1, Hongzhe Duan1, Rachel Holmes1
1Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA.
Abstract:
Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and slope of decline in weight, on AD risk. Women with late-onset-AD had lower weight three or more decades before AD onset, and ∼10 years younger AgeMax, compared to AD-free women. APOE4 carriers had younger AgeMax and steeper slope. Older AgeMax and flatter slope predicted lower AD risk. Premature decline in weight could be a sign of accelerated physical aging contributing to AD.
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