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Purified Versus Plasma Alpha-1 Antitrypsin Effects on Cellular Activities
1Alpha-1 Biologics, Long Island High Technology Incubator, Stony Brook University, Stony Brook, NY, USA. cynthia.bristow@alpha1biologics.com.
Abstract:
By adding purified exogenous alpha-1 antitrypsin (AAT) to peripheral blood mononuclear cells in 20% autologous serum and measuring AAT-induced cellular adherence, it was determined that purified AAT differs from plasma AAT. The known association of AAT with lipoproteins and the negative feedback between AAT and low-density lipoprotein (LDL) suggest that purification may separate AAT from a plasma component such as LDL that participates in their normal plasma functions.
