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Updated: Jul 8, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Circulating tumor DNA: current implementation issues and future challenges for clinical utility.

Qilin Hu¹, Lujun Chen², Kerui Li¹

¹Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, P.R. China.

Clinical Chemistry and Laboratory Medicine

|December 18, 2023

Summary

This summary is machine-generated.

Liquid biopsy using circulating tumor DNA (ctDNA) shows promise for cancer care. Further research and clinical studies are needed to overcome challenges and fully integrate these advanced noninvasive tests into oncology decision-making.

Keywords:

MRD ctDNA early detection immunotherapy targeted therapy

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Last Updated: Jul 8, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

Area of Science:

Oncology
Biotechnology
Genomics

Background:

Liquid biopsy, particularly circulating tumor DNA (ctDNA), is a noninvasive method for cancer detection and monitoring.
Advances in next-generation sequencing and AI have boosted liquid biopsy's accuracy and sensitivity, especially for solid tumors.

Purpose of the Study:

To propose a conceptual framework for ctDNA technologies and clinical applications.
To highlight challenges and future directions for ctDNA in clinical oncology.

Main Methods:

Bibliometric analysis of ctDNA technologies and clinical utilities.
Review of current literature on ctDNA applications in cancer.

Main Results:

ctDNA holds significant potential for early cancer diagnosis, relapse detection, therapy monitoring, and understanding drug resistance.
Integration of ctDNA tests into clinical decision-making faces complexities and challenges.

Conclusions:

Rigorous clinical studies and translational research are essential to support the therapeutic strategy decision-making process.
Future directions include enhancing ctDNA's role in early detection, minimal residual disease monitoring, targeted therapy, and immunotherapy.