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Updated: Jul 8, 2025
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
Published on: February 23, 2024
Impact of ketogenic diet on cardiovascular disease
Mohamed S Zaghloul1, Santiago Elizondo-Benedetto1, Mohamed A Zayed1,2,3,4,5
1Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Objectives:
A comprehensive review of the current literature was conducted to summarize the potential therapeutic and management roles of ketogenic diet (KD) for cardiovascular disease (CVD).
Background:
Consensus has not been reached on the optimal diet for individuals with cardiovascular risk factors. KDs are characterized by high-fat, low-carbohydrate, and appropriate protein content, and have gained popularity in recent years in the management of various conditions, including cardiovascular and metabolic diseases.
Methods:
Original research, systematic reviews, and meta-analyses available in the PubMed, Web of Science, and Google Scholar databases were reviewed.
Results:
The current body of preclinical and clinical evidence on the efficacy of KD in the management of CVD remains limited. Specific applications of KD seem to suggest a positive impact on management of CVD. However, conflicting results and a lack of precise molecular and biochemical mechanisms of action provide ample opportunity for future investigation.
Conclusion:
More multidisciplinary studies are needed to determine the true clinical benefit of KD in the management of CVD and so justify its expanded clinical use.
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