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Updated: Jul 8, 2025

Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1
Published on: April 8, 2009
Genome analysis of the mpox (formerly monkeypox) virus and characterization of core/variable regions
Zehui Yu1, Xiaoxia Zou2, Zhaobin Deng3
1Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, PR China; Laboratory Animal Center, Southwest Medical University, Luzhou, Sichuan, PR China; Scholl of Basic Medical Sciences, Zhejiang University, Hangzhou, PR China; Model Animal and Human Disease Research of Luzhou Key Laboratory, Luzhou, PR China.
Abstract:
Since smallpox was eradicated in 1980, the monkeypox virus (MPXV) has emerged as the most threatening orthopoxvirus in the world. In this study, we conducted a comprehensive analysis of the currently published complete genome sequences of the monkeypox virus. The core/variable regions were identified through core-pan analysis of MPXV. Besides single-nucleotide polymorphisms, our study also revealed that specific genes, multi-copy genes, repeat sequences, and recombination fragments are primarily distributed in the variable region. This result suggests that variable regions are not only more susceptible to single-base mutations, but also to events such as gene loss or gain, as well as recombination. Taken together, our results demonstrate the genomic characteristics of the core/variable regions of MPXV, and contribute to our understanding of the evolution of MPXV.
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