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Metal-organic framework-based advanced therapeutic tools for antimicrobial applications
Zhao Chen1, Fei Xing1, Peiyun Yu2
1Department of Orthopedic Surgery, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Acta Biomaterialia
|December 18, 2023
Summary
Metal-organic frameworks (MOFs) offer novel antimicrobial strategies beyond traditional antibiotics. This review details MOF synthesis, mechanisms, and applications in treating infections like wound infections and osteomyelitis.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Conventional antibiotics face increasing resistance, necessitating novel antimicrobial agents.
- Metal-organic frameworks (MOFs) show promise due to their tunable structures and diverse antimicrobial properties.
Purpose of the Study:
- To provide a comprehensive review of MOF synthesis and antimicrobial mechanisms.
- To explore advancements in MOF-based antimicrobial strategies and their clinical applications.
Main Methods:
- Review of literature on MOF synthesis and antimicrobial mechanisms.
- Analysis of MOF applications in wound infections, osteomyelitis, and periodontitis.
Main Results:
- MOFs exhibit antimicrobial activity through sustained release of agents, reactive oxygen species (ROS) generation, and photogenerated ROS.
- MOF-based materials demonstrate progress in treating various infections, including wound infections and osteomyelitis.
Conclusions:
- MOFs present a versatile platform for developing next-generation antimicrobial materials.
- Further research into MOF applications could overcome challenges in combating antibiotic resistance.
