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Updated: Jul 8, 2025

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

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Role of epithelial splicing regulatory protein 1 in cancer progression

Mi Jeong Kwon1,2

  • 1Vessel-Organ Interaction Research Center (MRC), College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea. mjkwon94@knu.ac.kr.

Cancer Cell International
|December 19, 2023
PubMed

Insights

Aberrant splicing factors drive cancer. Epithelial splicing regulatory protein 1 (ESRP1) has a dual role in cancer progression, impacting tumor growth and drug response, making it a potential therapeutic target.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Pharmacology

Background:

  • Aberrant alternative splicing, driven by splicing factor dysregulation or mutations, is implicated in cancer initiation and progression.
  • Splicing factors are emerging as critical therapeutic targets for cancer treatment.
  • Epithelial splicing regulatory protein 1 (ESRP1) is an epithelial cell-specific splicing factor involved in alternative splicing of key genes like CD44 and FGFR2.

Purpose of the Study:

  • To review the current understanding of ESRP1's roles and mechanisms in cancer progression.
  • To discuss the emerging novel roles of ESRP1 in cancer, including its impact on tumor metabolism and the tumor microenvironment.
  • To explore recent therapeutic strategies targeting splicing factors, particularly ESRP1, for cancer therapy.

Main Methods:

  • Literature review of studies investigating ESRP1's function in various cancer types.
  • Analysis of research on ESRP1's association with epithelial-mesenchymal transition (EMT) and its downstream targets.
  • Examination of studies exploring ESRP1's influence on tumor cell metabolism, immune cell infiltration, and drug response.

Main Results:

  • ESRP1 exhibits a dual role in cancer progression, acting as a tumor suppressor in some contexts and a promoter in others (e.g., breast and ovarian cancers).
  • ESRP1 downregulation is linked to EMT, while its expression levels correlate with patient prognosis and response to anticancer drugs.
  • Emerging evidence suggests ESRP1 influences tumor growth through regulation of tumor cell metabolism and immune cell infiltration within the tumor microenvironment.

Conclusions:

  • ESRP1 plays a complex and context-dependent role in cancer, extending beyond its known function in EMT.
  • Targeting ESRP1 and other splicing factors presents a promising avenue for novel cancer therapeutic strategies.
  • Further research into ESRP1's multifaceted roles in cancer biology and its interaction with the tumor microenvironment is warranted.
Keywords:
Alternative splicingCancer progressionDual roleEpithelial splicing regulatory protein 1Epithelial–mesenchymal transitionSplicing factor

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