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Primary Testicular Lymphoma Mimicking Germ-Cell Tumor: A Case Report
Murtadah Alnemer1, Jomana M Felemban2, Ali Mansoor1
1Urology, Dammam Medical Complex, Dammam, SAU.
Cureus
|December 19, 2023
Summary
Primary testicular non-Hodgkin lymphoma (NHL) is rare, presenting as a painless mass. This case highlights a B-cell lymphoma mimicking a germ cell tumor, emphasizing the need for thorough histopathology despite initial suspicions.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Primary testicular non-Hodgkin lymphoma (NHL) accounts for 1-2% of all lymphoma cases.
- It often presents as a painless testicular mass, with 35% of cases involving both testes.
Observation:
- A 42-year-old male presented with a three-month history of painless right scrotal swelling.
- Elevated βHCG was the only abnormal serologic marker; ultrasonography revealed a heterogeneous, low-echogenicity intra-testicular lesion.
Findings:
- Despite clinical suspicion for a germ cell tumor based on age, epidemiology, and presentation, histopathology confirmed B-cell non-Hodgkin lymphoma.
- Radical orchiectomy was performed, and the specimen analysis was crucial for diagnosis.
Implications:
- This case underscores the importance of considering extragonadal tumors, such as lymphoma, in the differential diagnosis of testicular masses.
- Accurate histopathological examination is essential for definitive diagnosis and appropriate management of testicular neoplasms, even when clinical indicators suggest otherwise.
