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Poor sleep quality association with higher lung cancer risk: a nested case-control study
Guo-Tian Ruan1,2,3, Ya-Ping Wei4, Yi-Zhong Ge1,2,3
1National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China.
Peerj
|December 19, 2023
Summary
Poor sleep quality is linked to a higher risk of lung cancer. Smokers with poor sleep face an even greater risk, highlighting the importance of addressing sleep issues for lung cancer prevention.
Area of Science:
- Epidemiology
- Oncology
- Sleep Medicine
Background:
- The relationship between sleep quality and lung cancer incidence is not well understood.
- Investigating this connection is crucial for public health and preventative strategies.
Purpose of the Study:
- To examine the association between sleep quality and the risk of developing lung cancer.
- To determine if smoking status modifies this relationship.
Main Methods:
- A nested case-control study was conducted using data from the Lianyungang cohort.
- 150 lung cancer cases and 150 matched controls were analyzed.
- Univariate and multivariate logistic regression models were employed.
Main Results:
- Poor sleep quality was significantly associated with an increased risk of lung cancer (OR=1.83, P=0.033).
- Stratified analysis revealed a stronger positive association between poor sleep quality and cancer risk in smokers.
- Smokers with poor sleep quality had a 2.79-fold higher incidence of lung cancer compared to non-smokers with good sleep quality.
Conclusions:
- Poor sleep quality is a significant risk factor for increased lung cancer incidence.
- The combination of smoking and poor sleep quality substantially elevates lung cancer risk.
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