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Correction: Sun et al. Engineered Adipose-Derived Stem Cells Overexpressing RXFP1 via CRISPR Activation Ameliorate Erectile Dysfunction in Diabetic Rats. <i>Antioxidants</i> 2023, <i>12</i>, 171.

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Related Experiment Video

Updated: Jul 8, 2025

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
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Exploring potential genes and mechanisms linking erectile dysfunction and depression.

Penghui Yuan1,2, Yinwei Chen3, Taotao Sun2

  • 1Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Endocrinology
|December 19, 2023
PubMed
Summary
This summary is machine-generated.

This study identified 85 common genes linking erectile dysfunction (ED) and depression, revealing shared molecular mechanisms. CLDN5 and TBC1D1 were validated as key crosslinks, offering insights into co-occurring ED and depression.

Keywords:
bioinformaticsbiomarkerdepressionerectile dysfunctionshared transcriptome

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Area of Science:

  • Molecular biology
  • Genomics
  • Neuroscience

Background:

  • Erectile dysfunction (ED) and depression share clinical correlations.
  • Evidence for shared underlying biological mechanisms between ED and depression is limited.
  • Transcriptomic alterations offer a potential avenue to explore shared pathways.

Purpose of the Study:

  • To identify common transcriptomic alterations between ED and depression.
  • To explore shared biological roles and molecular mechanisms.
  • To validate key genes linking ED and depression.

Main Methods:

  • Collected gene sets for ED and depression from the Gene Expression Omnibus (GEO) database.
  • Performed comparative analysis to identify common genes.
  • Conducted functional enrichment, network analysis, and molecular experiments for validation.

Main Results:

  • Identified 85 common genes associated with cell adhesion, redox homeostasis, and neuronal function.
  • Developed an interactive network and identified eight major shared genes, including CLDN5 and TBC1D1.
  • Validated CLDN5 and TBC1D1 as hub crosslinks located in the corpus cavernosum and brain tissue, respectively.

Conclusions:

  • This research is the first to investigate shared transcriptomic alterations between ED and depression.
  • Identified key molecular players and pathways contributing to the co-occurrence of ED and depression.
  • Provides insights into the molecular mechanisms underlying the link between ED and depression.