An insight into the structure-activity relationship studies of anticancer medicinal attributes of 7-azaindole
Neha Sharma1, Anurag Chaudhary2, Monika Sachdeva1
1Rajkumar Goel Institute of Technology (Pharmacy), NH-58, Ghaziabad, 201001, India.
Abstract:
In the current portfolio, there is a lot of interest in the 7-azaindole building block for drug discovery. The creation of synthetic, sophisticated methods for the modification of 7-azaindoles is a promising area of research. This review covers the structure-activity relationship of 7-azaindole analogs, which have been shown to be effective anticancer agents in the literature of the past two decades. Positions 1, 3 and 5 of the 7-azaindole ring are the most active sites. Disubstitution is used for the synthesis of a new analog of the 7-azaindole moiety. All positions are used to create novel molecules that are effective anticancer agents. The alkyl, aryl carboxamide group and heterocyclic ring are the most successful types of substitution.
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