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Published on: December 5, 2020
Precision Hypertension
Victor J Dzau1,2, Conrad P Hodgkinson1
1Mandel Center for Hypertension and Atherosclerosis, the Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC (V.J.D., C.P.H.).
Insights
Precision medicine offers a personalized approach to managing hypertension, addressing its global burden and complications. This strategy leverages advanced data science and omics to tailor treatments for better patient outcomes.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Data Science
Background:
- Hypertension impacts over 1 billion individuals globally, leading to severe complications like stroke and heart failure.
- Despite available treatments, uncontrolled hypertension remains a significant public health challenge.
- Current approaches often overlook patient diversity, hindering effective management.
Purpose of the Study:
- To review advancements in precision medicine for hypertension.
- To explore the potential of individualized treatment strategies.
- To highlight novel therapeutic and diagnostic approaches.
Main Methods:
- Review of current literature on precision medicine in hypertension.
- Analysis of emerging technologies including data science, omics, and artificial intelligence.
- Discussion of gene therapy and gene editing applications.
Main Results:
- Precision medicine promises more predictive and individualized hypertension management.
- Integration of omics data (genomics, metabolomics, proteomics) enhances treatment personalization.
- Artificial intelligence and advanced data analytics are crucial for interpreting complex patient data.
Conclusions:
- A precision medicine framework is essential for effectively managing hypertension.
- Future hypertension care will likely involve tailored interventions based on unique patient profiles.
- Technological advancements are paving the way for a new era in hypertension treatment.
Abstract:
Hypertension affects >1 billion people worldwide. Complications of hypertension include stroke, renal failure, cardiac hypertrophy, myocardial infarction, and cardiac failure. Despite the development of various antihypertensive drugs, the number of people with uncontrolled hypertension continues to rise. While the lack of compliance associated with frequent side effects to medication is a contributory issue, there has been a failure to consider the diverse nature of hypertensive populations. Instead, we propose that hypertension can only be truly managed by precision. A precision medicine approach would consider each patient's unique factors. In this review, we discuss the progress toward precision medicine for hypertension with more predictiveness and individualization of treatment. We will highlight the advances in data science, omics (genomics, metabolomics, proteomics, etc), artificial intelligence, gene therapy, and gene editing and their application to precision hypertension.
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