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Selenium prevented renal tissue damage in lipopolysaccharide-treated rats
Mahdiyeh Hedayati-Moghadam1,2, Fatemeh Seyedi3, Mahmoud Hosseini4
1Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.
Journal of Complementary & Integrative Medicine
|December 19, 2023
Summary
Selenium supplementation mitigated kidney damage caused by lipopolysaccharide (LPS) in rats. This study shows selenium reduces oxidative stress and inflammation, improving kidney function and antioxidant markers.
Area of Science:
- Nephrology
- Toxicology
- Biochemistry
Background:
- Kidney diseases are a significant cause of mortality and healthcare costs.
- Inflammatory responses and oxidative stress are key drivers in the progression of kidney diseases.
Purpose of the Study:
- To investigate the protective effects of selenium (Sel) against lipopolysaccharide (LPS)-induced kidney damage in a rat model.
- To evaluate selenium's impact on oxidative stress and inflammatory markers in the kidneys.
Main Methods:
- Wistar rats were divided into four groups: control, LPS-induced, and two LPS groups treated with different doses of selenium (0.1 and 0.2 mg/kg).
- LPS was administered intraperitoneally for 14 days to induce renal toxicity.
- Selenium treatment was administered concurrently with LPS for 14 days.
Main Results:
- Selenium treatment significantly reduced oxidative stress in kidney tissue, evidenced by improved antioxidant indicators like catalase (CAT) and superoxide dismutase (SOD) activities, and total thiol content.
- Malondialdehyde (MDA) levels and interleukin-6 (IL-6) in kidney homogenates were decreased by selenium administration.
- Selenium treatment inhibited the LPS-induced elevation of serum biochemical markers of kidney function, including blood urea nitrogen (BUN) and creatinine.
Conclusions:
- Selenium administration improves renal function in LPS-treated rats by ameliorating oxidative damage and inflammation.
- Further research is warranted to elucidate the precise mechanisms underlying selenium's effects on kidney outcomes in human subjects.
