HYPERACTIVE BLADDER SYNDROME SECONDARY TO BAROTRAUMA AND CHRONIC STRESS.

Area of Science:

• Urology
• Trauma Medicine
• Pharmacology

Background:

• Combat trauma can lead to barotrauma and chronic stress.
• These factors contribute to the development of hyperactive bladder syndrome in working-age men.
• Existing treatments may not adequately address the complex etiology in this population.

Purpose of the Study:

• To evaluate the efficacy of a treatment regimen for hyperactive bladder syndrome in men with combat-related barotrauma and stress.
• To assess the impact of solifenacin succinate on key symptoms of overactive bladder.

Main Methods:

• A clinical study involving 32 male patients with combat trauma-induced hyperactive bladder.
• Patients received a treatment complex including solifenacin succinate, an M3 receptor antagonist.
• Symptom severity was assessed over 8 weeks, focusing on urgency, frequency, and nocturia.

Main Results:

• 88% of patients experienced a positive treatment effect (≥50% symptom reduction) after 8 weeks.
• A 'good' result (≥75% improvement) was observed in 52% of patients.
• A 'satisfactory' result (50-75% improvement) was noted in 36% of patients.

Conclusions:

• The proposed treatment complex, including solifenacin succinate, demonstrates significant clinical effectiveness for hyperactive bladder syndrome in men with combat trauma.
• The treatment successfully alleviates symptoms such as urgency, frequency, and nocturia.
• Enhanced diagnostic vigilance is recommended for both specialists and general practitioners managing these patients.