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Establishing Fully-Automated Fundus-Controlled Dark Adaptometry: A Validation and Retest-Reliability Study.

Jeannine M Oertli1,2, Kristina Pfau1,3, Hendrik P N Scholl1,4,5

  • 1Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.

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Summary

A new fundus-controlled dark-adaptometry method was developed and validated, showing reliable results for localized visual cycle testing in eyes with unstable fixation.

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Area of Science:

  • Ophthalmology
  • Visual Neuroscience
  • Retinal Physiology

Background:

  • Accurate assessment of the visual cycle and retinoid transfer is crucial for understanding retinal diseases.
  • Localized testing of these functions is challenging in patients with unstable fixation.

Purpose of the Study:

  • To establish and validate a novel fundus-controlled dark-adaptometry method for precise localized testing.
  • To assess the validity and repeatability of this new method.

Main Methods:

  • Development of custom dark-adaptometry software for the S-MAIA device.
  • Validation substudy comparing the novel method with a comparator device (MonCvONE).
  • Retest reliability substudy using the S-MAIA device on the same participants.

Main Results:

  • The novel method demonstrated minimal between-method differences in key dark-adaptation parameters (cone-rod-break-time, rod-intercept-time, S2 slope).
  • High retest reliability was observed for all measured parameters, with narrow limits of agreement.
  • Valid and repeatable measurements of steady-state cone and rod thresholds were achieved.

Conclusions:

  • The developed fundus-controlled dark-adaptometry method provides valid and reliable results.
  • This technique addresses the need for localized visual cycle testing in challenging clinical scenarios.