Related Experiment Video
Updated: Jul 8, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Visible-Light-Driven Decarboxylative Borylation: Rapid Access to α- and β-Amino-boronamides
Andrea Serafino1, Hugo Pierre1,2, Franck Le Vaillant1,2
1Labcom HitCat, SEQENS-CNRS Joint Laboratory, SEQENS'Lab, 8 Rue de Rouen, 78440 Porcheville, France.
Abstract:
In this study, we described a two-step process involving an efficient visible-light-induced decarboxylative borylation of α- and β-amino redox-active esters with bis(catecholato)diboron, followed by transamination with 1,8-diaminonapthalene (DANH2). A series of boronamides were obtained in moderate to excellent yields in this one-pot procedure. The photochemical process proved to be very efficient even when conducted under flow conditions with shorter reaction durations and scalable synthesis of DAN boronates.
Related Concept Videos
α-Bromination of Carboxylic Acids: Hell–Volhard–Zelinski Reaction
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
α-Alkylation of Ketones via Enolate Ions
Preparation of Amines: Reductive Amination of Aldehydes and Ketones
Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation
One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism

