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Updated: Jul 8, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

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Seasonality and clinical characteristics of MS in an equatorial country

Simón Cárdenas-Robledo1, Laura Estefanía Arenas-Vargas1, Michael Steven Carvajal-Parra2

  • 1Centro de Esclerosis Múltiple (CEMHUN), Departamento de Neurología, Hospital Universitario Nacional de Colombia, Bogotá, Colombia; Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.

Multiple Sclerosis and Related Disorders
|December 19, 2023
PubMed
Abstract

Insights

Birth month and season do not impact multiple sclerosis (MS) onset age or severity in Colombian patients. This study found no significant links between birth timing and MS disease characteristics in this population.

Area of Science:

  • Neurology
  • Epidemiology
  • Environmental Health

Background:

  • Previous research suggests month and season of birth may influence multiple sclerosis (MS) risk.
  • However, limited evidence exists on their impact on MS onset timing and disease severity.

Purpose of the Study:

  • To investigate if birth month and season affect age at onset, phenotype, and severity of MS in a Colombian patient cohort.
  • To analyze the association between birth timing and primary progressive MS likelihood.

Main Methods:

  • Analysis of 668 confirmed multiple sclerosis cases from a prior case-control study.
  • Statistical evaluation of birth month and season's influence on age at onset, MS severity score, and age-related MS severity score.
  • Kaplan-Meier survival analysis and logistic regression models were used to assess onset and progression.

Main Results:

  • No statistically significant differences were observed in age at MS onset based on birth month or season.
  • Birth month and season did not significantly influence MS severity scores.
  • No significant association was found between birth timing and primary progressive MS.

Conclusions:

  • In the studied Colombian population, month and season of birth do not appear to be significant factors influencing the age of onset or phenotype of multiple sclerosis.
  • These findings contribute to understanding the environmental factors in MS etiology within a specific geographic context.
Keywords:
Age of onsetDisease progressionMonth of birthMultiple sclerosis chronic progressiveMultiple sclerosis relapsing remittingSeasonsSunlight

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