Dentin remineralization using a stimuli-responsive engineered small molecule GSK3 antagonists-functionalized adhesive

Area of Science:

• Biomaterials Science
• Dental Materials
• Regenerative Dentistry

Background:

• Tideglusib demonstrates potential in dentin regeneration.
• Evaluating the bonding efficacy of tideglusib-loaded nanoparticles (TG-NPs) in demineralized dentin is crucial for restorative applications.

Purpose of the Study:

• To assess the bonding ability of demineralized dentin infiltrated with polymeric nanoparticles (NPs) doped with tideglusib (TG-NPs).

Main Methods:

• Dentin surfaces were infiltrated with NPs and TG-NPs.
• Bonded interfaces were subjected to mechanical, chemical, and thermal challenges.
• Evaluations included confocal laser scanning microscopy and field emission scanning electron microscopy.

Main Results:

• TG-NP treated dentin exhibited superior bond strength after load cycling.
• Porosity and nanoleakage were reduced with TG-NP infiltration.
• Mineral deposits were observed at the hybrid layer and dentinal tubules.

Conclusions:

• Tideglusib-doped nanoparticles significantly improved dentin bonding efficacy.
• This technique facilitates mineral formation, reduces defects, and enhances sealing at the resin-dentin interface.
• Infiltrating etched dentin with TG-NPs is a reproducible method for inducing therapeutic bioactivity and creating reparative dentin.