Related Experiment Video

Updated: Jul 8, 2025

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

3.6K

Gastrointestinal perforation in extremely low birth weight infants: A single center retrospective study in China

Wei Feng1, Hong Zhang2, Huan Yan1

  • 1The Department of Pediatric Surgery, Chengdu Women's and Children' Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.

Pediatrics and Neonatology
|December 19, 2023
PubMed

Insights

Gastrointestinal perforation is a critical threat to extremely low birth weight infants. Sepsis and hemodynamically significant patent ductus arteriosus are key risk factors, while treatments like ibuprofen and blood transfusions improve survival rates.

Area of Science:

  • Neonatology
  • Pediatric Surgery
  • Critical Care Medicine

Background:

  • Gastrointestinal perforation (GIP) in extremely low birth weight infants (ELBWI) is a life-threatening condition with high mortality.
  • Characterized by rapid onset and severe complications, GIP necessitates understanding its risk factors and management strategies.

Purpose of the Study:

  • To investigate the clinical characteristics of pneumoperitoneum in ELBWI.
  • To identify risk factors for GIP in very low birth weight preterm infants.
  • To share surgical experiences in managing GIP in ELBWI.

Main Methods:

  • Retrospective study of ELBWI with GIP (birth weight <1000 g) from 2014-2021.
  • Risk factor identification using multiple logistic regression analysis.
  • Survival analysis using Kaplan-Meier and Cox multivariate regression models.

Main Results:

  • Significant risk factors for GIP in ELBWI include hemodynamically significant patent ductus arteriosus (hsPDA) and sepsis.
  • Intraventricular hemorrhage, sepsis, and GIP negatively impact ELBW infant survival.
  • Ibuprofen and blood transfusions demonstrate beneficial effects on survival.

Conclusions:

  • GIP significantly threatens ELBW infant survival, with hsPDA and sepsis as predisposing factors.
  • Distinct clinical characteristics of GIP necessitate tailored surgical interventions.
  • Understanding risk factors and survival predictors is crucial for managing GIP in ELBWI.
Abstract

Keywords:
Extremely low birth weight infantsGastrointestinal perforationRisk factorsSurgical treatmentSurvival rate

More Related Videos

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

1.9K
Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.3K

Related Concept Videos

Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
98
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
65