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Correlation between serum vitamin D level and uterine volume in girls with idiopathic central precocious puberty

Jun Sun1, Wei Wang1, Ya Xiao1

  • 1The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|December 19, 2023
PubMed

Insights

Idiopathic central precocious puberty (ICPP) girls show lower vitamin D and larger uterine volume. Lower vitamin D levels correlate with increased uterine volume in ICPP, unlike in normally developing peers.

Area of Science:

  • Pediatric Endocrinology
  • Reproductive Health
  • Nutritional Science

Background:

  • Idiopathic central precocious puberty (ICPP) is a condition characterized by early puberty onset.
  • Uterine volume is a key indicator of pubertal development.
  • Vitamin D's role in reproductive health is increasingly recognized.

Purpose of the Study:

  • To investigate the relationship between serum vitamin D levels and uterine volume in girls with ICPP.
  • To compare these findings with those in normally developing girls.

Main Methods:

  • Retrospective analysis of 278 ICPP cases and 239 controls (January 2017-September 2022).
  • Collection of clinical data and serum vitamin D levels.
  • Correlation and regression analyses, including subgroup analysis based on vitamin D status.

Main Results:

  • ICPP girls had significantly higher uterine volume and lower serum vitamin D compared to controls.
  • A weak negative correlation between vitamin D and uterine volume was observed in ICPP girls (r=-0.193, p=0.004), but not in controls.
  • Girls with vitamin D deficiency/insufficiency had larger uterine volumes than those with sufficient levels within the ICPP group.

Conclusions:

  • Serum vitamin D levels are inversely correlated with uterine volume in girls with ICPP.
  • Lower vitamin D levels and increased uterine volume are common in ICPP.
  • Further research is needed to elucidate vitamin D's role in ICPP pathogenesis and inform treatment strategies.
Abstract

Keywords:
estradiolhypothalamus-pituitary-gonadal axisidiopathic central precocious pubertyuterine volumevitamin D

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