Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Sclerodermiform porphyria].

N Simon, I Korom, L Szekeres

    Zeitschrift Fur Hautkrankheiten
    |November 15, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Is it Necessary to Perform Sentinel Lymph Node Biopsy in Thin Melanoma? A Retrospective Single Center Analysis.

    Pathology oncology research : POR·2019
    Same author

    Therapeutic challenge during the long-term follow-up of a patient with indolent systemic mastocytosis with extensive cutaneous involvement.

    European review for medical and pharmacological sciences·2015
    Same author

    BRAFV600E mutation in cutaneous lesions of patients with adult Langerhans cell histiocytosis.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2014
    Same author

    Comparative statistical analysis of osteoporosis treatment based on Hungarian claims data and interpretation of the results in respect to cost-effectiveness.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2014
    Same author

    The direct effect of specific training and walking on bone metabolic markers in young adults with peak bone mass.

    Acta physiologica Hungarica·2014
    Same author

    Evaluation of the effect of Lake Hévíz thermal mineral water in patients with osteoarthritis of the knee: a randomized, controlled, single-blind, follow-up study.

    European journal of physical and rehabilitation medicine·2014
    Same journal

    [Acne vulgaris: morphologic, endocrinologic and psychosomatic aspects].

    Zeitschrift fur Hautkrankheiten·1990
    Same journal

    [Anti-androgen treatment of hirsutism with cyproterone acetate].

    Zeitschrift fur Hautkrankheiten·1990
    Same journal

    [Changes in sunscreening products in West Germany between 1988 and 1989/90].

    Zeitschrift fur Hautkrankheiten·1990
    Same journal

    [Effect of treatment with salt from the Dead Sea (Tomesa therapy) on epidermal Langerhans cells--a clinical study].

    Zeitschrift fur Hautkrankheiten·1990
    Same journal

    [DNA determination by cytophotometry in bowenoid papules in comparison with condylomata acuminata and Bowen's disease].

    Zeitschrift fur Hautkrankheiten·1990
    Same journal

    [Adverse drug reactions on hair].

    Zeitschrift fur Hautkrankheiten·1990
    See all related articles

    Sclerodermiform changes in porphyria cutanea tarda (PCT) are rare and not solely due to phototoxicity. Porphyrins with 4 or 5 COOH-groups may contribute to pathogenesis via a "dark-effect".

    Area of Science:

    • Dermatology
    • Biochemistry
    • Pathogenesis

    Context:

    • Porphyria cutanea tarda (PCT) is a metabolic disorder characterized by porphyrin accumulation.
    • Sclerodermiform changes are rare but observed complications of PCT.
    • Understanding the pathogenesis of these changes is crucial for patient management.

    Purpose:

    • To investigate the clinical, histological, biochemical, and pathogenetic aspects of sclerodermiform changes in PCT patients.
    • To explore the correlation between dermatological symptoms, porphyrin metabolism, and sclerodermiform changes.
    • To elucidate the role of different porphyrin types and potential mechanisms in the development of these complications.

    Summary:

    • A retrospective study identified sclerodermiform changes in 12 PCT patients (2% of cases).

    Related Experiment Videos

  • No correlation was found between symptom severity and porphyrin metabolism disturbance; biochemical remission did not improve skin changes.
  • Patients with sclerodermiform changes showed a higher proportion of porphyrins with 4 or 5 COOH-groups compared to PCT patients without sclerosis.

    • Impact:

    • Findings suggest that phototoxic reactions alone do not explain sclerodermiform changes in PCT.
    • The
    • dark-effect
    • of porphyrins is implicated as a significant factor in the pathogenesis of these sclerodermiform changes.
    • This research may lead to improved understanding and therapeutic strategies for PCT complications.