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Updated: Jul 8, 2025

Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time
Published on: July 1, 2014
Functional connectivity patterns in parosmia
Divesh Thaploo1, Akshita Joshi2, Eren Yilmaz3
1Smell & Taste Clinic, Department of Otorhinolaryngology, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. Taploodivesh4@gmail.com.
Objective:
Parosmia is a qualitative olfactory dysfunction presenting as "distorted odor perception" in presence of an odor source. Aim of this study was to use resting state functional connectivity to gain more information on the alteration of olfactory processing at the level of the central nervous system level.
Methods:
A cross sectional study was performed in 145 patients with parosmia (age range 20-76 years; 90 women). Presence and degree of parosmia was diagnosed on the basis of standardized questionnaires. Participants also received olfactory testing using the "Sniffin' Sticks". Then they underwent resting state scans using a 3 T magnetic resonance imaging scanner while fixating on a cross.
Results:
Whole brain analyses revealed reduced functional connectivity in salience as well as executive control networks. Region of interest-based analyses also supported reduced functional connectivity measures between primary and secondary olfactory eloquent areas (temporal pole, supramarginal gyrus and right orbitofrontal cortex; dorso-lateral pre-frontal cortex and the right piriform cortex).
Conclusions:
Participants with parosmia exhibited a reduced information flow between memory, decision making centers, and primary and secondary olfactory areas.
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