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Microfluidics-Based Blood Typing Devices: An In-Depth Overview.

Arjun Jayachandran1, Shahila Parween2, Amit Asthana1

  • 1Department of Medical Devices, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.

ACS Applied Bio Materials
|December 20, 2023
PubMed
Summary

Decentralized blood typing using paper-based microfluidic devices offers rapid, low-cost testing for resource-limited settings. This review highlights advancements and challenges for sustainable, widespread adoption in blood transfusion services.

Keywords:
AgglutinationBiofunctionalizationBlood TypingImmunoassayPaper-Based Microfluidics

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Area of Science:

  • Biomedical Engineering
  • Point-of-Care Diagnostics
  • Materials Science

Background:

  • Accurate blood typing is critical for patient care, transfusions, and understanding disease.
  • Centralized labs are often impractical, necessitating decentralized testing solutions.
  • Microfluidic devices offer rapid, portable blood typing capabilities.

Purpose of the Study:

  • To review recent developments in microfluidic blood typing devices.
  • To assess the potential for decentralized blood typing in resource-limited settings.
  • To identify challenges and opportunities for long-term sustainability and commercialization.

Main Methods:

  • Review of recent scientific literature on microfluidic blood typing.
  • Analysis of paper-based microfluidic platforms for blood typing advantages.
  • Evaluation of integration with digital technologies for improved accuracy.

Main Results:

  • Paper-based microfluidic devices offer advantages like pump-free operation and biodegradability.
  • These devices enable rapid, easy blood typing protocols suitable for decentralized use.
  • Challenges remain for mass commercialization, requiring focus on sustainability.

Conclusions:

  • Microfluidic blood typing holds significant promise for accessible diagnostics.
  • Addressing sustainability and integrating digital tools are key for widespread adoption.
  • Further development can overcome limitations for large-scale implementation.