Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:19

Cell Migration

4.9K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
4.9K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.8K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.8K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

2.3K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.3K
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

5.3K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.3K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.4K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

2.7K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Moo-ving mountains: grazing agents drive terracette formation on steep hillslopes.

Journal of the Royal Society, Interface·2026
Same author

Distinguishable spreading dynamics in microbial communities.

Biophysical journal·2026
Same author

Effects of cell-cell communication on bacterial chemotaxis.

Physical review. E·2026
Same author

Seabird trajectories map onto a reduced optimal-control bound for dynamic soaring.

ArXiv·2026
Same author

Fast, long-range intercellular signal propagation through growth-assisted positive feedback.

Cell systems·2026
Same author

Colony morphogenesis regulates sporulation dynamics in bacterial biofilms.

bioRxiv : the preprint server for biology·2026
Same journal

Erratum: Low-dimensional model for adaptive networks of spiking neurons [Phys. Rev. E 111, 014422 (2025)].

Physical review. E·2026
Same journal

Disentangling the effects of many-body forces on depletion interactions.

Physical review. E·2026
Same journal

Charge transport and mode transition in dual-energy electron beam diodes.

Physical review. E·2026
Same journal

Optimization of multisite reactions in complex compartmentalized media.

Physical review. E·2026
Same journal

Origin of geometric cohesion in nonconvex granular materials: Interplay between interdigitation and rotational constraints enhancing frictional stability.

Physical review. E·2026
Same journal

Interaction of walkers with a standing Faraday wave.

Physical review. E·2026
See all related articles

Related Experiment Video

Updated: Jul 8, 2025

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.1K

Collective effects in flow-driven cell migration.

Louis González1, Andrew Mugler1

  • 1Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Physical Review. E
|December 20, 2023
PubMed
Summary
This summary is machine-generated.

High-density cell clusters can move faster through autologous chemotaxis than individual cells when using temporal gradient sensing. This collective behavior emerges from cells forming a shared sensory unit, challenging previous assumptions about cell density limitations.

More Related Videos

Using the Dot Assay to Analyze Migration of Cell Sheets
09:42

Using the Dot Assay to Analyze Migration of Cell Sheets

Published on: December 5, 2017

6.9K
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.6K

Related Experiment Videos

Last Updated: Jul 8, 2025

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.1K
Using the Dot Assay to Analyze Migration of Cell Sheets
09:42

Using the Dot Assay to Analyze Migration of Cell Sheets

Published on: December 5, 2017

6.9K
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.6K

Area of Science:

  • Cellular Biology
  • Biophysics
  • Computational Biology

Background:

  • Autologous chemotaxis guides cells using self-secreted molecules.
  • High cell densities typically impair autologous chemotaxis due to signal interference.

Purpose of the Study:

  • Investigate autologous chemotaxis at high cell densities.
  • Determine if collective cell behavior can overcome density-dependent signal interference.

Main Methods:

  • Three-dimensional Monte Carlo simulation.
  • Coupled spatial and temporal gradient sensing with cell-cell repulsion.
  • Computational fluid dynamics and analytic scaling arguments.

Main Results:

  • High-density cell clusters chemotax faster than individual cells when temporal gradient sensing dominates.
  • Temporal gradient sensing enables cells to form a collective sensory unit.
  • Clusters exhibit superior signal anisotropy detection compared to single cells.

Conclusions:

  • Collective autologous chemotaxis at high cell densities is feasible.
  • This phenomenon relies on known and common cellular capabilities.
  • Temporal gradient sensing is key to enhanced collective cell migration.