MESENCHYMAL CELLS IN ROTATOR CUFF REPAIR - TECHNIQUE DESCRIPTION AND CASE REPORTS.

Area of Science:

• Orthopedic Surgery
• Regenerative Medicine
• Cell Therapy

Background:

• Rotator cuff tears are common injuries impacting shoulder function.
• Current surgical repair methods aim to restore tendon integrity and function.
• Biological adjuvants are being explored to enhance healing and outcomes.

Purpose of the Study:

• To detail the protocol for obtaining mesenchymal stem cells (MSCs).
• To evaluate the efficacy of MSCs as a biological adjuvant in arthroscopic rotator cuff repair.
• To report outcomes in patients receiving MSC-augmented rotator cuff surgery.

Main Methods:

• A case series involving three patients with isolated full-thickness supraspinatus tears.
• Arthroscopic rotator cuff repair utilizing autologous bone marrow-derived MSCs.
• MSCs applied at the tendon-bone interface at a concentration of 2 million cells/mm³ in 5 ml volume.

Main Results:

• All three patients demonstrated clinical improvement post-procedure.
• One patient achieved an excellent result, and two achieved good results.
• Complete tendon healing was confirmed in all cases, with no re-tears or complications observed.

Conclusions:

• Arthroscopic rotator cuff repair augmented with expanded bone marrow-derived MSCs yielded positive functional results.
• The use of MSCs as a biological adjuvant promoted tendon healing in all treated patients.
• No adverse events or complications were reported, suggesting a safe therapeutic approach.