A Neutral Flavin-Triphenylamine Probe for Mitochondrial Bioimaging under Different Microenvironments
Harsha Gopal Agrawal1, Pravin Shankar Giri2, Poonam Meena1
1Department of Chemistry, Indian Institute of Technology, Sangareddy, Hyderabad 502285, Telangana, India.
ACS Medicinal Chemistry Letters
|December 20, 2023
Abstract:
A bioinspired design built around a neutral flavin-triphenylamine core has been investigated for selective mitochondrial bioimaging capabilities in different microenvironments. Significant advantages with respect to long-term tracking, faster internalization, penetrability within the spheroid structures, and strong emission signal under induced hypoxia conditions have been observed, which could offer an alternative to the existing mitotrackers for hypoxia-related biological events.


