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Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications.

João Borges1, Jinfeng Zeng2, Xi Qiu Liu3

  • 1CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.

Advanced Healthcare Materials
|December 20, 2023
PubMed
Summary
This summary is machine-generated.

Layer-by-layer (LbL) assembly creates functional biomaterial surfaces for drug delivery and tissue engineering. Recent advances enhance LbL film construction for diverse biomedical applications.

Keywords:
biomaterialscell signalingdrug deliverygrowth factorslayer‐by‐layerregenerative medicinetissue engineering

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Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Biotechnology

Background:

  • Layer-by-layer (LbL) assembly is a versatile technique for creating thin films using complementary molecules.
  • This method is well-suited for biomaterials due to its simplicity, biocompatibility, and adaptability to various supports.
  • LbL films offer controlled immobilization of bioactive molecules and tunable mechanical properties.

Purpose of the Study:

  • To review recent advancements in LbL films for drug delivery and tissue engineering.
  • To highlight emerging applications in vaccinology and biomimetic tissue models.
  • To present novel technological developments in LbL film construction.

Main Methods:

  • Review of recent literature on LbL assembly for biomedical applications.
  • Focus on 2D and 3D LbL film fabrication and characterization.
  • Discussion of emerging construction technologies like high-content liquid handling and machine learning.

Main Results:

  • LbL films are increasingly utilized in drug delivery systems and tissue engineering scaffolds.
  • Applications span vaccinology, 3D biomimetic tissue models, bone, and cardiovascular tissue regeneration.
  • New construction methods promise accelerated development and broader applicability of LbL technology.

Conclusions:

  • LbL assembly remains a powerful tool for developing functional biomaterial surfaces.
  • Continued innovation in fabrication and application is expanding its impact in biomedicine.
  • Emerging technologies are poised to revolutionize LbL film development and deployment.