Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bacterial Signaling

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Cytoskeletal Proteins in Bacteria

Cytoskeletal Proteins in Bacteria

Bacterial cells were initially considered simple, randomly organized structures lacking a cytoskeleton. However, the discovery of cytoskeleton homologs in bacteria led to the change of this opinion. Bacterial cytoskeletal filaments regulate the cell shape, cell polarity, cell division, and partitioning of plasmids during cell division. It was later discovered that bacterial cytoskeletal proteins, mainly actin and tubulin homologs, are diverse compared to their eukaryotic counterparts. On the...

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...

Antibiotic Selection

Antibiotic Selection

Surface Membrane Barriers

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Type VII-secreted toxin enables inter-mycobacterial competition.

Nature communications·2026

Same author

The <i>Staphylococcus aureus</i> LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model.

Microbiology (Reading, England)·2025

Same author

Distinct immunity protein families mediate compartment-specific neutralization of a bacterial toxin.

Cell reports·2025

Same author

Distinct immunity protein families mediate compartment-specific neutralisation of a bacterial toxin.

bioRxiv : the preprint server for biology·2025

Same author

Modularity of Zorya defense systems during phage inhibition.

Nature communications·2025

Same author

High-throughput functional analysis provides novel insight into type VII secretion in <i>Staphylococcus aureus</i>.

Open biology·2024

Search research articles

Related Experiment Video

Updated: Jul 8, 2025

Quantification of Interbacterial Competition using Single-Cell Fluorescence Imaging

Quantification of Interbacterial Competition using Single-Cell Fluorescence Imaging

Published on: September 2, 2021

Interbacterial competition mediated by the type VIIb secretion system.

Eleanor R Boardman¹, Tracy Palmer¹, Felicity Alcock¹

¹Microbes in Health and Disease Theme, Newcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Microbiology (Reading, England)

|December 20, 2023

Summary

This summary is machine-generated.

The type VIIb secretion system (T7SSb) in Bacillota bacteria aids in niche colonization by secreting toxins and facilitating interactions. This system is crucial for interbacterial competition and virulence in Gram-positive bacteria.

Keywords:

T7SS bacterial competition contact-dependent inhibition protein secretion toxin type VII secretion system

More Related Videos

Coincubation Assay for Quantifying Competitive Interactions between Vibrio fischeri Isolates

Coincubation Assay for Quantifying Competitive Interactions between Vibrio fischeri Isolates

Published on: July 22, 2019

A Visual Assay to Monitor T6SS-mediated Bacterial Competition

A Visual Assay to Monitor T6SS-mediated Bacterial Competition

Published on: March 20, 2013

Related Experiment Videos

Last Updated: Jul 8, 2025

Quantification of Interbacterial Competition using Single-Cell Fluorescence Imaging

Quantification of Interbacterial Competition using Single-Cell Fluorescence Imaging

Published on: September 2, 2021

Coincubation Assay for Quantifying Competitive Interactions between Vibrio fischeri Isolates

Coincubation Assay for Quantifying Competitive Interactions between Vibrio fischeri Isolates

Published on: July 22, 2019

A Visual Assay to Monitor T6SS-mediated Bacterial Competition

A Visual Assay to Monitor T6SS-mediated Bacterial Competition

Published on: March 20, 2013

Area of Science:

Microbiology
Bacterial Physiology
Molecular Biology

Background:

Bacterial colonization requires extensive interaction with the environment and resident microbes.
Bacteria utilize diverse protein secretion systems for these interactions, with eleven identified to date.
The type VIIb secretion system (T7SSb) is a key system in Bacillota.

Conclusions:

The T7SSb is a multifunctional secretion system vital for Bacillota.
Understanding T7SSb mechanisms and substrates is crucial for comprehending bacterial ecology and pathogenesis.
T7SSb is a key determinant of bacterial success in competitive environments.