Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

2.5K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.5K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

1.9K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.9K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.5K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.5K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

4.6K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoperative parathyroid hormone level as a predictor of parathyroid adenoma size in surgically treated patients with primary hyperparathyroidism.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2026
Same author

Molecular Genetic Aspects of Sporadic Multiglandular Primary Hyperparathyroidism.

Physiological research·2023
Same author

Age-Related Changes in Proinsulin Processing in Normoglycemic Individuals.

Physiological research·2023
Same author

Surgical treatment of hyperparathyroidism with a pathologically changed parathyroid gland found in the mediastinum.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2023
Same author

[Surgical Treatment of Tuberculous Spondylodiscitis].

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2023
Same author

[Modified Harrington Procedure in the Treatment of Extensive Tumor Defects of the Acetabulum].

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2023

Related Experiment Video

Updated: Jul 8, 2025

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

3.5K

Recurrent Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type 1 Syndrome.

P Libánský1, J Čarková, I Kushnir

  • 13rd Department of Surgery, 1st Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic. petr.libansky@lf1.cuni.cz.

Physiological Research
|December 20, 2023
PubMed
Summary

Patients with Multiple Endocrine Neoplasia Type 1 (MEN1) syndrome have a higher risk of requiring reoperation for primary hyperparathyroidism. Early genetic testing can improve surgical planning and outcomes for these individuals.

More Related Videos

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

1.9K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

14.6K

Related Experiment Videos

Last Updated: Jul 8, 2025

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

3.5K
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

1.9K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

14.6K

Area of Science:

  • Endocrinology
  • Genetics
  • Surgical Oncology

Background:

  • Primary hyperparathyroidism is a prevalent endocrine disorder.
  • Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare genetic syndrome predisposing to endocrine tumors, including primary hyperparathyroidism.
  • Reoperation rates for primary hyperparathyroidism can be significant.

Purpose of the Study:

  • To evaluate the reoperation rates in patients with primary hyperparathyroidism.
  • To determine if MEN1 syndrome influences the need for reoperation in these patients.
  • To highlight the importance of preoperative identification of MEN1 syndrome.

Main Methods:

  • Retrospective analysis of 1011 patients undergoing surgery for primary hyperparathyroidism between 2018-2022.
  • Identification of patients with MEN1 syndrome within the cohort.
  • Comparison of reoperation rates between MEN1 patients and the general primary hyperparathyroidism cohort.

Main Results:

  • Overall reoperation rate was 8% (78 patients).
  • 27 patients (2.7% of total cohort) had MEN1 syndrome.
  • 35% (7 of 27) of MEN1 patients required reoperation, significantly higher than the general cohort.
  • Patients with MEN1 syndrome demonstrated a higher risk of needing reoperation.

Conclusions:

  • MEN1 syndrome is associated with an increased risk of reoperation for primary hyperparathyroidism.
  • Preoperative genetic testing for MEN1 syndrome is crucial for risk stratification.
  • Informed surgical approaches are necessary for MEN1 patients to minimize reoperations.