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Hemangiopericytoma of meninges. II. General and clinical data
Abstract:
Meningeal hemangiopericytoma (HP) has mostly been viewed as a variant of meningioma. There is more and more evidence, however, that HP constitutes a separate entity among tumors of the central nervous system. The data of intracranial and spinal HP of 17 of our patients and from a review of the literature is compared to meningioma and to peripheral HP. Meningeal and peripheral HP present with a similar sex ratio, age distribution, tendency to metastasize and are almost never multiple. This is fundamentally different from meningioma. Other data of meningeal HP like interval between first operation and manifestation of a recurrence or metastasis and survival time cannot be compared to peripheral HP due to its special location. Prognosis of meningeal HP is distinctly worse than of meningioma, placing HP between malignancy grade I and II as specified by WHO.
Insights
Meningeal hemangiopericytoma (HP) is increasingly recognized as distinct from meningioma, showing similar metastatic tendencies and prognosis to peripheral HP. This central nervous system tumor has a worse prognosis than meningioma.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Pathology
Background:
- Meningeal hemangiopericytoma (HP) has historically been classified as a meningioma variant.
- Emerging evidence suggests HP is a distinct entity within central nervous system tumors.
Purpose of the Study:
- To compare intracranial and spinal HP with meningioma and peripheral HP.
- To evaluate the distinct characteristics and prognosis of meningeal HP.
Main Methods:
- Analysis of 17 patient cases of intracranial and spinal HP.
- Comparative review of literature data for meningeal HP, meningioma, and peripheral HP.
Main Results:
- Meningeal and peripheral HP share similar sex ratios, age distributions, metastatic tendencies, and rarity of multiplicity, differing significantly from meningioma.
- Prognosis for meningeal HP is considerably worse than for meningioma, aligning with WHO malignancy grades I-II.
Conclusions:
- Meningeal hemangiopericytoma represents a separate entity from meningioma.
- Meningeal HP exhibits distinct clinical and prognostic features compared to meningioma, warranting separate classification.