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Updated: Jul 8, 2025
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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
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ICTV Virus Taxonomy Profile: Tulasviridae 2023
Jens H Kuhn1, Scott Adkins2, Katherine Brown3
1Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick MD 21702, USA.
The Journal of General Virology
|December 20, 2023
Summary
The Tulasviridae family comprises fungal ambisense RNA viruses. Their genomes encode nucleoprotein, RNA-directed RNA polymerase, and an unknown protein, as detailed in the ICTV report.
Area of Science:
- Virology
- Mycology
- Molecular Biology
Background:
- Fungi host a diverse range of viruses, including RNA viruses.
- Ambisense RNA viruses represent a unique genomic strategy.
- The Tulasviridae family is a recently characterized group of fungal viruses.
Purpose of the Study:
- To summarize the International Committee on Taxonomy of Viruses (ICTV) report on the Tulasviridae family.
- To provide an overview of the genomic characteristics and protein-encoding genes of Tulasviridae.
Main Methods:
- Review and synthesis of the official ICTV classification and description of the Tulasviridae family.
- Analysis of the genomic structure and open reading frames (ORFs) of Tulasviridae.
Main Results:
- Tulasviridae is an ambisense RNA virus family found in fungi.
- The viral genome is nonsegmented and approximately 12.2 kb in size.
- Three ORFs encode a nucleoprotein (NP), a large (L) protein with an RNA-directed RNA polymerase (RdRP) domain, and a protein of unknown function (X).
Conclusions:
- The Tulasviridae family has distinct genomic features, including ambisense RNA replication.
- Further research is needed to elucidate the function of the 'X' protein.
- This summary provides a foundational understanding of Tulasviridae for the scientific community.
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