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Updated: Jul 8, 2025

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Published on: April 15, 2013
Thermoinduced Radical Cyclization for the Synthesis of Sultines
Zhiming Zhu1,2, Zhengxi Deng1,2, Chenglong Xuan1,2
1CCNU-uOttawa Joint Research Centre, National Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, College of Chemistry, Central China Normal University (CCNU), Wuhan, Hubei 430070, China.
Abstract:
A thermoinduced radical homolytic substitution cyclization of alkenyl tethered sulfinate esters was displayed under mild metal-free conditions, enabling the functionalization of alkenes and leading to structurally diverse value-added sultine products. The process utilizes readily available substrates using inexpensive 5% benzoyl peroxide (BPO) as an initiator to generate functionalized sultines with broad functional group tolerance in medium to excellent yields in a highly atom-economical manner. In addition, the obtained sultines could be further readily functionalized toward valuable sultone frameworks in one pot. A thermo-catalytic radical chain process was proposed based on mechanistic studies.
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