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Updated: Jul 8, 2025

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
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Interplay Between TGF-β Signaling and MicroRNA in Diabetic Cardiomyopathy

Jianning Qin1, Yao Tan1, Yang Han1

  • 1Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hongxiang Street, Hengyang, 421001, Hunan, China.

Cardiovascular Drugs and Therapy
|December 20, 2023
PubMed

Insights

Diabetic cardiomyopathy (DCM) involves heart complications in diabetes patients. This review explores the interplay between transforming growth factor-beta (TGF-β) signaling and microRNAs (miRNAs) in DCM, seeking new therapeutic targets.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Endocrinology

Background:

  • Cardiovascular disease is a major cause of death in diabetic patients.
  • Diabetic cardiomyopathy (DCM) is a diabetes-associated condition leading to heart failure.
  • Transforming growth factor-beta (TGF-β) signaling is implicated in myocardial remodeling and disorders.

Purpose of the Study:

  • To review the intricate relationship between TGF-β signaling and microRNAs (miRNAs) in the context of DCM.
  • To identify potential therapeutic targets by understanding the cross-talk between these pathways.

Main Methods:

  • Literature review focusing on the molecular mechanisms linking TGF-β and miRNA in DCM.
  • Analysis of existing research on TGF-β isoforms, SMADs, and miRNA regulation in diabetic hearts.

Main Results:

  • TGF-β pathway components are frequently targeted by miRNAs.
  • TGF-β signaling, directly or via SMADs, influences miRNA synthesis.
  • These interactions suggest a complex regulatory network in DCM.

Conclusions:

  • The cross-talk between TGF-β and miRNA pathways represents a significant area for therapeutic intervention in DCM.
  • Further research into this interaction could lead to novel treatments for diabetic heart disease.

Keywords:
Diabetic cardiomyopathyMicroRNATGF-β signaling pathway

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