Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incremental Prognostic Value of Cardiac Magnetic Resonance Beyond Biomarker Staging in Transthyretin Cardiac Amyloidosis.

European heart journal. Cardiovascular Imaging·2026
Same author

Apixaban versus warfarin for anticoagulation after left ventricular assist device implantation: A multicenter real-world analysis.

JHLT open·2026
Same author

Multimodal Artificial Intelligence for Cardiac Amyloidosis Diagnosis: Integrating Echocardiography With Clinical and Laboratory Data for Improved Detection.

Circulation. Cardiovascular imaging·2026
Same author

Valve involvement in infective endocarditis among intravenous drug users: a systematic review and meta-analysis.

BMC infectious diseases·2026
Same author

Postpartum Left Ventricular Dysfunction in Preeclampsia With Incidental Patent Ductus Arteriosus: A Multimodality Hemodynamic Assessment.

Cureus·2026
Same author

Mid-Field Cardiovascular MRI in Class III Obesity.

JACC. Case reports·2026

Related Experiment Video

Updated: Jul 8, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.1K

Risk stratification in patients with structurally normal hearts: Does fibrosis type matter?

Katarzyna E Gil1, Katarzyna Mikrut2, Jan Mazur3

  • 1The Ohio State University Division of Cardiovascular Medicine, Columbus, OH, United States of America.

Plos One
|December 20, 2023
PubMed
Summary

Nonischemic myocardial fibrosis assessed by late gadolinium enhancement (LGE) is common in normal hearts but not linked to poor outcomes. However, elevated extracellular volume fraction (ECV) predicts all-cause mortality and aids risk stratification.

More Related Videos

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts
07:10

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Published on: May 16, 2021

4.7K
Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts
10:45

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

Published on: March 12, 2020

16.0K

Related Experiment Videos

Last Updated: Jul 8, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.1K
Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts
07:10

Refined CLARITY-Based Tissue Clearing for Three-Dimensional Fibroblast Organization in Healthy and Injured Mouse Hearts

Published on: May 16, 2021

4.7K
Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts
10:45

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

Published on: March 12, 2020

16.0K

Area of Science:

  • Cardiovascular Imaging
  • Cardiac Pathology
  • Prognostic Biomarkers

Background:

  • The clinical significance of myocardial abnormalities detected by cardiovascular magnetic resonance (CMR) in individuals with structurally normal hearts is not well understood.
  • Nonischemic myocardial fibrosis (MF) is increasingly recognized in this population.

Purpose of the Study:

  • To evaluate the prognostic value of nonischemic MF, assessed via late gadolinium enhancement (LGE) and extracellular volume fraction (ECV), in patients with structurally normal hearts.
  • To determine the association of LGE and ECV with all-cause mortality, new-onset heart failure (HF), and arrhythmic outcomes.

Main Methods:

  • A cohort of 525 patients with structurally normal hearts undergoing CMR was analyzed.
  • Macroscopic MF was assessed using LGE, and diffuse MF using ECV derived from T1 mapping.
  • Outcomes including all-cause mortality, new-onset HF, and arrhythmic events were tracked over a median follow-up of 5.8 years.

Main Results:

  • Nonischemic LGE was found in 52.9% of patients, with no significant association with mortality or new-onset HF.
  • An increase in ECV was significantly associated with all-cause mortality (HR per 1% increase: 1.19; p=0.009), even after multivariable adjustment (HR: 1.26; p=0.009).
  • Neither LGE nor ECV showed a significant association with arrhythmic outcomes.

Conclusions:

  • Nonischemic LGE is prevalent in patients with structurally normal hearts but does not predict adverse cardiovascular events.
  • Elevated ECV is an independent predictor of all-cause mortality in this cohort.
  • ECV quantification may serve as a valuable tool for risk stratification in patients with structurally normal hearts.