Nonenzymatic Glucose Sensor Using Bimetallic Catalysts.
Rashmi Ghosh1, Xiao Li1, Matthew Z Yates1
1Department of Chemical Engineering, University of Rochester, Rochester, New York 14627, United States.
ACS Applied Materials & Interfaces
|December 20, 2023
Summary
New bimetallic electrocatalysts (Ag@Ni and Cu@Ni) were developed for glucose oxidation. These nonenzymatic glucose sensors exhibit high sensitivity and accuracy, even in complex biological samples.
Area of Science:
- Electrochemistry
- Materials Science
- Analytical Chemistry
Background:
- Development of efficient electrocatalysts is crucial for nonenzymatic glucose sensing.
- Bimetallic nanostructures offer enhanced catalytic properties compared to monometallic counterparts.
Purpose of the Study:
- To synthesize and characterize novel bimetallic electrocatalysts for glucose oxidation.
- To evaluate the performance of these electrocatalysts as nonenzymatic glucose sensors.
Main Methods:
- Electrochemical deposition of Nickel followed by Silver or Copper onto a titanium electrode.
- Characterization using X-ray diffraction, spectroscopy (EDS, XPS), and electron microscopy.
- Electrocatalytic activity and sensing performance assessed via cyclic voltammetry and amperometry.
Main Results:
- Successfully synthesized Ag@Ni and Cu@Ni bimetallic structures with high surface area.
- Demonstrated superior electrocatalytic activity for glucose oxidation compared to Nickel alone.
- Developed a nonenzymatic glucose sensor with high sensitivity and low detection limit.
- Cu@Ni catalyst accurately measured glucose in the clinically relevant range (0.2-12 mM) and showed good anti-interference properties.
Conclusions:
- Bimetallic nanostructures significantly enhance glucose oxidation electrocatalysis.
- The developed Cu@Ni coated electrode is a promising candidate for accurate and reliable nonenzymatic glucose monitoring.
- This sensor technology holds potential for applications in diabetes management and diagnostics.
