Related Experiment Videos
Left ventricular derived cardiac output
Insights
Cardiac output (CO) can now be accurately measured using left ventricular (LV) injection of indocyanine green dye. This method offers a simpler alternative to traditional right-sided cardiac catheterization for CO determination.
Area of Science:
- Cardiology
- Medical Imaging
- Physiology
Background:
- Right-sided cardiac catheterization is the standard for measuring cardiac output (CO).
- Left-sided cardiac catheterization is more common in suspected coronary artery disease, often omitting CO measurement.
- There is a need for a less invasive method to measure CO.
Purpose of the Study:
- To determine if cardiac output (CO) can be accurately measured from the left side of the heart.
- To evaluate the efficacy of indocyanine green dye injection into the left ventricle (LV) for CO measurement.
Main Methods:
- 24 patients undergoing cardiac catheterization were studied.
- Near-simultaneous determination of CO using indocyanine green dye injected into the pulmonary artery and the LV cavity.
- Comparison of CO measurements derived from both injection sites.
Main Results:
- Close agreement was found between pulmonary artery and LV-derived cardiac outputs (Pulmonary artery = 0.93 LV + 0.12).
- Pulmonary artery derived CO averaged 5.7 ± 2.0 L/min; LV derived CO averaged 6.1 ± 2.2 L/min.
- Pulmonary artery and LV derived stroke volumes showed a close relation (82 ± 33 ml vs. 86 ± 36 ml).
Conclusions:
- Cardiac output can be accurately measured by injecting indocyanine green dye into the left ventricular cavity.
- This provides a viable alternative for CO assessment, potentially simplifying cardiac catheterization procedures.
Abstract:
Measurement of cardiac output (CO) requires right-sided cardiac catheterization. However, to save time and reduce costs, only left-sided cardiac catheterization is usually performed in most patients with suspected coronary artery disease. Thus, CO is not measured. To determine if CO can be measured from the left side of the heart, 24 patients undergoing cardiac catheterization had near-simultaneous determination of CO after indocyanine green dye was injected into the pulmonary artery and left ventricular (LV) cavity. There was close agreement between pulmonary artery and LV derived cardiac outputs (Pulmonary artery = 0.93 LV + 0.12). The pulmonary artery derived CO was 5.7 +/- 2.0 liters/min and the LV derived CO was 6.1 +/- 2.2 liter/min. Also, there was a close relation between pulmonary artery derived stroke volume (82 +/- 33 ml) and LV derived stroke volume (86 +/- 36 ml). Thus, CO can be accurately measured after injection of indocyanine green dye into the LV cavity.