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SENTRI: Single-Particle Energy Transducer for Radionuclide Injections for Personalized Targeted Radionuclide Cancer

Kyoungtae Lee1, Rahul Lall2, Shalini Chopra3

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PubMed
Summary
This summary is machine-generated.

A novel silicon chiplet dosimeter enables real-time monitoring of radiation dose during targeted radionuclide therapy (TRT). This technology helps personalize TRT by tracking dose deposition in tumors and organs, improving treatment efficacy for metastatic cancer.

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Area of Science:

  • Medical Physics
  • Nuclear Medicine
  • Biomedical Engineering

Background:

  • Targeted radionuclide therapy (TRT) offers systemic radiation delivery for metastatic cancer.
  • Patient outcomes in TRT are limited by significant inter-patient variability in dose delivery.
  • Personalized TRT strategies require real-time monitoring of dose deposition in tumors and organs at risk.

Purpose of the Study:

  • To develop and validate a novel in vivo dosimeter for real-time monitoring of radiation dose during TRT.
  • To assess the dosimeter's capability in tracking dose distribution in tumors and organs at risk.
  • To enable personalized TRT by providing precise, continuous dose information.

Main Methods:

  • A 0.27-mm³ monolithic silicon chiplet dosimeter with an array of 64x64 micro-diodes was designed and fabricated.
  • The dosimeter integrates signal amplifiers, buffers, and on-chip memory for direct tumor implantation.
  • In vivo studies utilized PC3-PIP (PSMA+) and PC3-flu (PSMA-) cell lines in mice, measuring 177Lu-PSMA-617 activity at multiple time points post-injection, verified with SPECT/CT.

Main Results:

  • The dosimeter demonstrated a wide detection range (0.013–8.95 MBq/mL), accurately measuring both high tumor uptake and low organ doses in real time.
  • Measured activity showed high linearity (R² > 0.99) with 177Lu-PSMA-617 levels.
  • In vivo measurements correlated well with SPECT/CT data, with an acceptable error margin of ±1.5% ID/mL.

Conclusions:

  • The developed silicon chiplet dosimeter successfully provides real-time, in vivo measurement of radionuclide activity.
  • The system's verification in a prostate cancer mouse model using 177Lu-PSMA-617 supports its potential clinical application.
  • This technology can significantly enhance personalized TRT by enabling precise dose monitoring and optimization.